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Abstract #4509

Saturation transfer MRI of creatine, phosphocreatine and glycogen in patients with Charcot-Marie-Tooth (CMT) disease

Xinran Chen1,2, Xingwen Sun3, Xiaoxuan Liu4, Chongxue Bie1, Lin Chen2, Huishu Yuan3, and Yang Zhou1
1Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province, Shenzhen Institute of Advanced Technology, Shenzhen, China, 2Department of Electronic Science, Xiamen University, Xiamen, China, 3Department of Radiology, Peking University Third Hospital, Beijing, China, 4Department of Neurology, Peking University Third Hospital, Beijing, China

Synopsis

Keywords: Muscle, CEST / APT / NOE, CMT, fat accumulation

Motivation: There remains an unmet need for sensitive biomarkers for CMT disease progression.

Goal(s): To explore the feasibility of evaluating CMT1A progression based on saturation transfer imaging of phosphocreatine, creatine, and glycogen at 5T.

Approach: Phosphocreatine and total creatine were detected via CEST effects at +2.6 ppm and +2.0 ppm of Z-spectrum, respectively, and glycogen was measured by relayed nuclear Overhauser effects at -1.0 ppm.

Results: Preliminary results showed an apparent decrease of PCrCEST and glycoNOE signals in the calf muscles of CMT1A patients, with the extent of signal reduction correlating with CMT1A severity.

Impact: Simultaneous monitoring of Cr, PCr and glycogen in muscle holds potential for tracking CMT progression and may offer a promising non-invasive approach for monitoring muscular disorders in humans.

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Keywords