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Abstract #4513

Investigation of processing and acquisition parameters on calculation of PCr recovery rates

Cherie Shook1, Lauren Sparks1, Paul Coen1, Bret Goodpaster1, and Heather Cornnell1
1AdventHealth Research Institute, AdventHealth Orlando, Orlando, FL, United States

Synopsis

Keywords: Muscle, Spectroscopy

Motivation: Changes in acquisition and processing parameters may impact calculated PCr Recovery results and inhibit cross study comparisons.

Goal(s): The purpose of this study is to determine the impact of alterations in acquisition and processing parameters on calculation of rate of phosphocreatine (PCr) recovery.

Approach: The PCr recovery rates of 141 volunteers were calculated with total acquisition times of 10 min, 7.5 min and 5 minutes and the resultant k values were compared.

Results: Although all calculated recovery rates were similar, shorter acquisition times resulted in faster recovery times. Therefore, it is important to use the same processing parameters to compare across studies.

Impact: 31P spectroscopy acquisition and processing parameters should be carefully documented to ensure comparable results across studies. Future studies should consider investigating the calculation or assumption of PCr and ATP concentrations.

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Keywords