Meeting Banner
Abstract #4517

A Comparative Study of CrCEST and PCrCEST for Mapping of Oxidative Phosphorylation in Exercised Muscle

Blake Benyard1, Anshuman Swain1, Abeer Mathur1, Narayan Datt Soni2, Ryan Armbruster1, Sunil Khokhar2, Mahammad Haris2, Neil Wilson2, Ravinder Reddy2, and Dushyant Kumar2
1University of Pennsylvania, Philadelphia, PA, United States, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Muscle, MSK

Motivation: This study compares the sensitivity and specificity of two CEST-based methods for assessing oxidative phosphorylation (OXPHOS) in participants' skeletal muscle and also shows that creatine in muscle is a fast-exchanging species.

Goal(s): We compare the sensitivity and specificity of creatine CEST and phosphocreatine CEST for exercised calf muscle.

Approach: We acquired z-spectra at multiple saturation parameters to compare creatine CEST and phosphocreatine CEST at 3.0T and 7.0T. We also acquired creatine CEST and phosphocreatine CEST from exercised calf muscle.

Results: Our findings indicate that creatine rapidly exchanges in skeletal muscle. Additionally, creatine CEST demonstrates higher sensitivity and specificity than phosphocreatine CEST.

Impact: OXPHOS deficiency in skeletal muscle is associated with primary mitochondrial disorders, muscle injury, cardiovascular disease, and diabetes mellitus. This study compares the sensitivity and specificity of two CEST-based methods for assessing OXPHOS.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords