Keywords: Muscle, MSK
Motivation: This study compares the sensitivity and specificity of two CEST-based methods for assessing oxidative phosphorylation (OXPHOS) in participants' skeletal muscle and also shows that creatine in muscle is a fast-exchanging species.
Goal(s): We compare the sensitivity and specificity of creatine CEST and phosphocreatine CEST for exercised calf muscle.
Approach: We acquired z-spectra at multiple saturation parameters to compare creatine CEST and phosphocreatine CEST at 3.0T and 7.0T. We also acquired creatine CEST and phosphocreatine CEST from exercised calf muscle.
Results: Our findings indicate that creatine rapidly exchanges in skeletal muscle. Additionally, creatine CEST demonstrates higher sensitivity and specificity than phosphocreatine CEST.
Impact: OXPHOS deficiency in skeletal muscle is associated with primary mitochondrial disorders, muscle injury, cardiovascular disease, and diabetes mellitus. This study compares the sensitivity and specificity of two CEST-based methods for assessing OXPHOS.
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