Abstract #4519

Association between Muscle Function, Quantitative MRI, and Phosphorus-31 MRS Parameters in Heart Failure Patients with Sarcopenia

Kihwan Kim^1,2, Brendan Eck^1,2, Valesha Province³, Jessie Kasper³, Silvio Nunes Augusto Junior³, Jennifer Wilcox³, Timothy Engelman³, W.H. Wilson Tang³, and Xiaojuan Li^2,4

¹Department of Diagnostic Radiology, Imaging institute, Cleveland Clinic, Cleveland, OH, United States, ²Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States, ³Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States, ⁴Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Muscle, Muscle, Sarcopenia, 31P-MRS, Quantitative MRI, Heart failure

Motivation: Quantitative MRI (qMRI) and phosphorus-31 (³¹P-MRS) show promise for assessing muscle quality and mitochondrial function, particularly in heart failure (HF) patients with sarcopenia, a condition of progressive muscle loss and dysfunction.

Goal(s): This study examines whether qMRI and ³¹P-MRS can distinguish muscle quality and relate to muscle function in HF patients with and without sarcopenia.

Approach: qMRI measures (T₁, T₂, T_1ρ, proton density fat fraction [PDFF]) and ³¹P-MRS (metabolite ratios, PCr recovery) were compared between non-sarcopenic and sarcopenic HF patients and correlated with muscle function.

Results: While qMRI values did not differ, T₁, T_1ρ, and PDFF correlated with function in sarcopenic HF patients.

Impact: This study highlights the potential of qMRI and ³¹P-MRS to noninvasively characterize muscle quality and mitochondrial function in HF patients with sarcopenia, which could inform targeted interventions.

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