Abstract #4526

Quantifying Iron, Protein Deposits, and Myelin Integrity in Parkinson’s Disease and Multiple System Atrophy

Jiaqi Wen^1,2, Jingjia Chen², Xiaojun Guan¹, Xiaojie Duanmu¹, Jianmei Qin¹, Zihao Zhu¹, Weijin Yuan¹, Qianshi Zheng¹, Cheng Zhou¹, Haoting Wu¹, Tao Guo¹, Chenqing Wu¹, Yong Zhang³, Minming Zhang¹, Chunlei Liu⁴, and Xiaojun Xu¹

¹Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, ²Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³GE Healthcare, Shanghai, China, ⁴Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United States

Synopsis

Keywords: Parkinson's Disease, Quantitative Susceptibility mapping, Multiple System Atrophy; Iron; Myelin

Motivation: The neurodegenerative patterns of Parkinson's disease (PD) and multiple system atrophy (MSA) remain to be explored.

Goal(s): To investigate the nigrostriatal iron, α-synuclein deposition, and white matter myelin integrity in the PD and MSA.

Approach: DECOMPOSE-QSM was applied in 184 old normal controls (ONC), 321 PD, and 22 MSA patients to quantify nigrostriatal iron, α-synuclein content, and white matter myelin content.

Results: PD and MSA show caudate protein and nigral iron deposition; putamen iron deposition is unique to MSA. The corticospinal tract was demyelinated in PD, while some accompanying fibers showed compensatory myelination. MSA exhibits compensatory myelination in cerebellar pathways.

Impact: This study clarifies distinct neurodegenerative patterns in PD and MSA, highlighting specific iron and protein deposition and myelin integrity alterations, potentially aiding targeted diagnostics and treatments of synucleinopathies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.