Keywords: Parkinson's Disease, Parkinson's Disease, Phosphorous MRS, Iron Deposition, Mitochondrial Dysfunction
Motivation: The mechanisms behind pathological iron deposition in Parkinson's Disease (PD) are unclear, with mitochondrial dysfunction possibly driving this accumulation in the brain.
Goal(s): To identify early biomarkers that better correlate with clinical symptoms in early-stage PD and to explore the links between mitochondrial dysfunction, iron deposition, and symptoms.
Approach: Utilize 1H/31P MRI to assess iron deposition and phosphorus metabolites in the substantia nigra (SN) and putamen of early PD patients.
Results: Early PD patients exhibit mitochondrial dysfunction, while significant iron deposition and abnormal volumes in the SN and putamen are not yet apparent.
Impact: Mitochondrial dysfunction may precede brain iron deposition in PD, and has the potential to serve as a critical early indicator.
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