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Abstract #4532

Brain iron Deposition and Mitochondrial Dysfunction in Early-Stage Parkinson’s Disease

Qiurong Yu1,2, Naying He1, Jinyuan Weng3, Peng Wu3, Baoyi Zhang2, Wenwen Dai2, Youmin Zhang1,2, and Fuhua Yan1,2
1Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Philips Healthcare, Shanghai, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, Phosphorous MRS, Iron Deposition, Mitochondrial Dysfunction

Motivation: The mechanisms behind pathological iron deposition in Parkinson's Disease (PD) are unclear, with mitochondrial dysfunction possibly driving this accumulation in the brain.

Goal(s): To identify early biomarkers that better correlate with clinical symptoms in early-stage PD and to explore the links between mitochondrial dysfunction, iron deposition, and symptoms.

Approach: Utilize 1H/31P MRI to assess iron deposition and phosphorus metabolites in the substantia nigra (SN) and putamen of early PD patients.

Results: Early PD patients exhibit mitochondrial dysfunction, while significant iron deposition and abnormal volumes in the SN and putamen are not yet apparent.

Impact: Mitochondrial dysfunction may precede brain iron deposition in PD, and has the potential to serve as a critical early indicator.

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