Abstract #4537

Defining Brain Atrophy Subtypes in Parkinson's Disease with Distinct Therapeutic Effects of Deep Brain Stimulation

Zhizheng Zhuo¹, Yutong Bai², Tiantan Hua¹, Xianchang Zhang³, and Yaou Liu¹

¹Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ²Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ³MR Research Collaboration Team, Siemens Healthiness Ltd., Beijing, China

Synopsis

Keywords: Parkinson's Disease, Brain

Motivation: Parkinson's disease (PD) patients in advanced stages harbor heterogeneous outcomes of deep brain stimulation (DBS) treatment.

Goal(s): To develop pre-surgical imaging classification of PD patients to guide DBS therapy.

Approach: The Subtype and Stage Inference model was used to identify distinct brain atrophy subtypes among PD patients by deviations from normative reference. Clinical variables and post-DBS motor outcomes across atrophy subtypes and stages were finally analyzed.

Results: Three distinct spatiotemporal brain atrophy subtypes were identified in PD, with distinct clinical and prognostic features.

Impact: The novel PD imaging subtypes can aid clinical decision-making regarding the optimal subtype and timing for DBS therapy.

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