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Abstract #4540

Assessing abnormal oxygen extraction fraction (OEF) and neural tissue susceptibility in Parkinson’s Disease

Arpita Misra1, Ana Maria Oros-Peusquens2, Imis Dogan3,4, Kathrin Reetz3,4, N. Jon Shah2,3,5,6, and Junghun Cho1
1Biomedical engineering, State university of new York at buffalo, Buffalo, NY, United States, 22INM-4, Research Centre Jülich, Julich, Germany, 3Department of Neurology, RWTH Aachen University, Achen, Germany, 4JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Research Centre Jülich, Julich, Germany, 5Faculty of Medicine, JARA, RWTH Aachen University, Achen, Germany, 6Institute of Neuroscience and Medicine 11, INM-11, JARA, Research Centre, Julich, Germany

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, Oxygenation, oxygen extraction fraction, quantitative susceptibility mapping, quantitative blood oxygen level dependent imaging, QSM, qBOLD, QSM+qBOLD, QQ

Motivation: Although Parkinson's disease (PD) is highly prevalent, its pathophysiology, particularly abnormal oxygen extraction fraction (OEF) and neural tissue susceptibility ($$$\chi_{n}$$$ ), remains unclear.

Goal(s): Compare OEF and $$$\chi_{n}$$$ between PD and healthy control (HC) and investigate their associations with age (PD risk factor) and cognitive impairment (measured by MMSE).

Approach: A novel MRI technique, QQ, estimates OEF and $$$\chi_{n}$$$ in cortical(CGM) and deep gray matter(DGM).

Results: PD showed higher OEF and $$$\chi_{n}$$$ than HC. In PD, OEF was associated negatively with $$$\chi_{n}$$$ in CGM and positively with MMSE in DGM. In both PD and HC, $$$\chi_{n}$$$ was associated positively with MMSE and age.

Impact: This study demonstrates QQ’s feasibility for detecting abnormal oxygen metabolism and iron accumulation in PD. Using a single routine MRI sequence, QQ is readily applicable for investigating PD pathophysiology and other neurologic disorders.

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Keywords