Abstract #4549
Impaired Blood Brain Barrier in Parkinson’s Disease: A DCE-MRI study
Sapir Fajerzstein1, Gadi Maayan Eshed2,3, Avner Thaler3,4,5,6,7, Anat Mirelman5,6,7, Tamara Shiner2,5,6,8, Nir Giladi3,5,6, Roy Alcalay3,5,9, Rotem Orad5,8, Noa Bregman2,5,6,8, Sheida Mirloo10, Lyna Kamintsky10, Moran Artzi5,6,11, Uri Nevo6,12, Dan Z Milikovsky2,13, and Dafna Ben Bashat5,6,11
1Biomedical Engineering, The Iby and Aladar Fleischman Faculty of Engineering TAU; Israel, Tel Aviv, Israel, 2Department of Neurology, Neurological Institute, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel, 3Movement Disorders Unit, Neurological Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel, Tel Aviv, Israel, 4Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, 5Sackler Faculty of Medicine, Tel Aviv University (TAU); Israel, Tel Aviv, Israel, 6Sagol School of Neuroscience, Tel Aviv University; Israel, Tel Aviv, Israel, 7Laboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel, Tel Aviv, Israel, 8Cognitive Neurology Unit, Neurological Institute, Tel Aviv Medical Center, Tel Aviv, Israel, Tel Aviv, Israel, 9Genomic Research Laboratory for Neurodegeneration, Tel-Aviv Medical Center, Tel-Aviv, Israel, Tel Aviv, Israel, 10Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada, Halifax, NS, Canada, 11Sagol Brain Institute, Tel Aviv Sourasky Medical Center (TASMC); Israel, Tel Aviv, Israel, 12The Iby and Aladar Fleischman Faculty of Engineering TAU; Israel, Tel Aviv, Israel, 13University of Toronto, Department of Medicine, Division of Neurology, University Health Network, Stroke Program, Toronto, ON, Canada, Toronto, ON, Canada
Synopsis
Keywords: Parkinson's Disease, Parkinson's Disease, Permeability, DCE Perfusion
Motivation: Blood-brain barrier dysfunction (BBBd) plays a role in several neurological disorders like epilepsy and Alzheimer’s Disease. However, In Parkinson’s Disease (PD), evidence on BBBd is limited.
Goal(s): To assess the feasibility of detecting BBBd by using Dynamic-contrast enhanced (DCE)-MRI in PD patients and study its association with cognitive manifestations.
Approach: DCE-MRI scans of age-matched controls and PD patients were analyzed using the extended Tofts model and a slow accumulation metric.
Results: Findings indicate higher permeability and lower vascularity in PD patients compared with controls in several brain regions.
Impact: This study demonstrates that DCE-MRI can detect BBB dysfunction in PD, marked by higher permeability and lower vascularity, offering insights for diagnostics, biomarker discovery, and BBB-targeted treatment development in Parkinson's disease.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
