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Abstract #4551

Assessment of white matter changes and grey matter atrophy in a 6-OHDA Parkinson's model

Maurizio Bergamino1, Alberto Fuentes1, Ivette M Sandoval1, David J Marmion1, Christopher Bishop2, Shuyi Zhu1,3, Fredric P Manfredsson1, and Ashley M Stokes1
1Barrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States, 2Department of Psychology, Binghamton University, Binghamton, NY, United States, 3School of Life Sciences, Arizona State University, Tempe, AZ, United States

Synopsis

Keywords: Parkinson's Disease, Animals

Motivation: To better understand Parkinson’s disease (PD)-related brain changes through a reliable animal model.

Goal(s): Use the 6-OHDA rat model to explore neurodegeneration in PD.

Approach: Applied free-water diffusion tensor imaging (fw-DTI) and voxel-based morphometry (VBM) to measure white matter microstructure and gray matter atrophy in PD-affected rats.

Results: 6-OHDA rats showed significant motor impairments and loss of dopamine neurons. fw-DTI indicated increased free-water content (suggesting neuroinflammation), and VBM revealed gray matter atrophy.

Impact: This study shows that free-water DTI and VBM are effective tools for examining Parkinson’s disease-related brain degeneration, providing insights into neurodegenerative mechanisms such as neuroinflammation and gray matter atrophy linked to PD progression.

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