Keywords: Parkinson's Disease, Animals
Motivation: To better understand Parkinson’s disease (PD)-related brain changes through a reliable animal model.
Goal(s): Use the 6-OHDA rat model to explore neurodegeneration in PD.
Approach: Applied free-water diffusion tensor imaging (fw-DTI) and voxel-based morphometry (VBM) to measure white matter microstructure and gray matter atrophy in PD-affected rats.
Results: 6-OHDA rats showed significant motor impairments and loss of dopamine neurons. fw-DTI indicated increased free-water content (suggesting neuroinflammation), and VBM revealed gray matter atrophy.
Impact: This study shows that free-water DTI and VBM are effective tools for examining Parkinson’s disease-related brain degeneration, providing insights into neurodegenerative mechanisms such as neuroinflammation and gray matter atrophy linked to PD progression.
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