Keywords: Neurofluids, Neurofluids
Motivation: Choroid plexus (ChP) function reflects important processes of the neurofluid circuit, but quantification of perfusion and other parameters requires quantitative knowledge of water density.
Goal(s): To quantify ChP water density at high spatial resolution over the course of a day.
Approach: 70 proton density MRIs were performed from 15 healthy controls at 7:00-9:00, 11:00-13:00, 16:00-18:00, and 19:00-21:00, and ChP water density was calculated.
Results: Across all measures, the ChP water density was calculated to be 0.918 ± 0.080 mL water / mL ChP. There was no significant change in ChP water density throughout the day (p=0.95).
Impact: Determining choroid plexus (ChP) water density will provide a method for accurate calculation of ChP perfusion, leading to an improved physiological understanding of the role of the ChP as the most proximal component of the neurofluid circuit.
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