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Abstract #4557

The Choroid Plexus Water Density in Humans Assessed from High-Spatial Resolution Proton Density MRI: Normative Values and Effect of Time of Day

Abigail Ruth Dubois1, Maeve Curtin1, Alexander K Song1, Melanie Leguizamon1, Maria Garza1, Kilian Hett1, Colin D McKnight2, Ciaran Considine1, and Manus Donahue1,3
1Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: Choroid plexus (ChP) function reflects important processes of the neurofluid circuit, but quantification of perfusion and other parameters requires quantitative knowledge of water density.

Goal(s): To quantify ChP water density at high spatial resolution over the course of a day.

Approach: 70 proton density MRIs were performed from 15 healthy controls at 7:00-9:00, 11:00-13:00, 16:00-18:00, and 19:00-21:00, and ChP water density was calculated.

Results: Across all measures, the ChP water density was calculated to be 0.918 ± 0.080 mL water / mL ChP. There was no significant change in ChP water density throughout the day (p=0.95).

Impact: Determining choroid plexus (ChP) water density will provide a method for accurate calculation of ChP perfusion, leading to an improved physiological understanding of the role of the ChP as the most proximal component of the neurofluid circuit.

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