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Abstract #4560

High-resolution practical imaging of perivascular spaces

Manuel Taso1, Christopher Brown2, Ilya M Nasrallah3, David A Wolk2, and John A Detre2,3
1Siemens Medical Solutions USA Inc, Malvern, PA, United States, 2Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Neurofluids, Alzheimer's Disease, perivascular spaces; glymphatics; neurodegeneration

Motivation: Perivascular spaces are of high relevance to the pathophysiology of Alzheimer's Disease, particularly in the context of anti-amyloid therapies.

Goal(s): To evaluate the feasibility of imaging PVS using ultra-long TE 3D-T2 sequence across field strengths.

Approach: We implemented a high-resolution protocol using an ultra-long-TE 3D T2-weighted TSE sequence at 1.5T and 3T, and scanned a cohort of healthy volunteers and AD patients.

Results: Improved definition of PVS was obtained using our ultra-long-TE protocol compared to standard methods, and shown to be feasible across field strengths. Pilot scans in AD patients show widespread increased signal.

Impact: This work demonstrates that perivascular spaces can be imaged in a clinically compatible time across field-strengths. Pilot scans in AD patients show widespread increased signal, suggesting a potential interest in specifically studying PVS in AD.

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Keywords