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Abstract #4568

Quantitative Evaluation of Low-Frequency Oscillation in Blood and CSF Flow and its Changes from Eye Open to Eye Closed

Haoze Zhu1, Pan Liu2,3, Elodie Foster1, Ning Jin4, Xiaopeng Zhou5, Olivier Balédent2,3, and Qiuting Wen1
1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 2CHIMERE UR 7516, Jules Verne University of Picardy, Amiens, France, 3Medical Image Processing Department, CHU Amiens-Picardy University Hospital, Amiens, France, 4MR R&D Collaborations, Siemens Medical Solution USA, Malvern, PA, United States, 5School of Health Sciences, Purdue University, West Lafayette, IN, United States

Synopsis

Keywords: Neurofluids, Neurofluids, Blood Vessels, Real time phase contrast

Motivation: Low-frequency oscillations (LFO) are a key driver of brain waste clearance, yet their role in CSF has only been qualitatively assessed using fMRI, lacking quantitative evaluation.

Goal(s): To quantitatively evaluate LFO in blood and CSF flows and study changes with drowsiness.

Approach: Arterial, venous, and CSF flow at the cervical level (C2/C3) were measured using real-time phase-contrast MRI, with measurements once with the eye open and once after a 30-minute eye closure. Band power from LFO, respiration, and cardiac pulsations were analyzed.

Results: LFO shows an increase from awake to drowsy in all fluid compartments, despite contributing small to overall oscillations.

Impact: Cervical CSF flow shows LFO at 3%, below respiration (13%) and cardiac (84%), contrasting with LFO>cardiac at the fourth ventricle in fMRI. The consistent LFO increase from alert to drowsy suggests a role in enhancing fluid clearance during sleep.

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