Keywords: Neurofluids, Neurofluids, Blood Vessels, Real time phase contrast
Motivation: Low-frequency oscillations (LFO) are a key driver of brain waste clearance, yet their role in CSF has only been qualitatively assessed using fMRI, lacking quantitative evaluation.
Goal(s): To quantitatively evaluate LFO in blood and CSF flows and study changes with drowsiness.
Approach: Arterial, venous, and CSF flow at the cervical level (C2/C3) were measured using real-time phase-contrast MRI, with measurements once with the eye open and once after a 30-minute eye closure. Band power from LFO, respiration, and cardiac pulsations were analyzed.
Results: LFO shows an increase from awake to drowsy in all fluid compartments, despite contributing small to overall oscillations.
Impact: Cervical CSF flow shows LFO at 3%, below respiration (13%) and cardiac (84%), contrasting with LFO>cardiac at the fourth ventricle in fMRI. The consistent LFO increase from alert to drowsy suggests a role in enhancing fluid clearance during sleep.
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