Meeting Banner
Abstract #4571

Enlargement of perivascular spaces is associated with accelerated Aβ accumulation

Lingyun Liu1, Qingze Zeng1, Hui Hong1, Miao Lin1, Ruiting Zhang1, and Peiyu Huang1
1Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Synopsis

Keywords: Alzheimer's Disease, Neurodegeneration

Motivation: Enlargement of perivascular spaces (PVS) has been found associated with Alzheimer’s disease.

Goal(s): To explore whether PVS burden modifies the trajectory of Aβ accumulation.

Approach: PVS volumes were obtained using an automated PVS segmentation tool, and Aβ deposition was evaluated using PET. Linear mixed models were applied to investigate the association between baseline PVS burden and Aβ deposition rates.

Results: A higher baseline basal ganglia PVS burden was associated with faster rates of Aβ accumulation.

Impact: We found that higher PVS burden is associated with faster rates of Aβ accumulation. This insight enhances our understanding of mechanisms and trajectory of Aβ accumulation, which could aid in developing therapeutic strategies to delay the progression of Alzheimer’s disease.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords