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Abstract #4577

Evaluation of Surgery for Improving Brain Glymphatic Circulation in Slowing Advanced Alzheimer’s Disease Progression by Glymphatic MRI

Hairong Ma1, Songtao Ai1, Pu-Yeh Wu2, and Yixin Zhang3
1Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2GE Healthcare, Beijing, China, Beijing, China, 3Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, Glymphatic MRI

Motivation: MRI technology can be used to assess glymphatic system function and to determine if it can detect changes before and after surgery.

Goal(s): This study examines changes in perivascular networks in AD patients before and after surgery as measured by MRI.

Approach: Using MRI, we measured brain volume in healthy controls and in AD patients before and after surgery, focusing on PVSVF, FW-WM, and ALPS index.

Results: Preoperative AD patients, compared to controls, showed reduced brain volume, increased cerebrospinal fluid volume, elevated FW-WM, and decreased ALPS index. Postoperatively, one patient exhibited reduced FW-WM and an increase in ALPS.

Impact: A decrease in ALPS indicates a lower cerebrospinal fluid clearance rate in AD patients, while increased FW-WM suggests fluid accumulation in the brain’s interstitial space. Postoperative changes imply improved cerebrospinal fluid clearance and a reduction in prior accumulation.

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