Keywords: Alzheimer's Disease, Alzheimer's Disease, Glymphatic MRI
Motivation: MRI technology can be used to assess glymphatic system function and to determine if it can detect changes before and after surgery.
Goal(s): This study examines changes in perivascular networks in AD patients before and after surgery as measured by MRI.
Approach: Using MRI, we measured brain volume in healthy controls and in AD patients before and after surgery, focusing on PVSVF, FW-WM, and ALPS index.
Results: Preoperative AD patients, compared to controls, showed reduced brain volume, increased cerebrospinal fluid volume, elevated FW-WM, and decreased ALPS index. Postoperatively, one patient exhibited reduced FW-WM and an increase in ALPS.
Impact: A decrease in ALPS indicates a lower cerebrospinal fluid clearance rate in AD patients, while increased FW-WM suggests fluid accumulation in the brain’s interstitial space. Postoperative changes imply improved cerebrospinal fluid clearance and a reduction in prior accumulation.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords