Keywords: Aging, Aging, Glymphatic system
Motivation: Glymphatic system(GS), as a brain waste clearance system, has been implicated in many neurodegenerative diseases . However, evidence is limited in a normal ageing population. Indicators based on magnetic resonance imaging (MRI) are the most promising methods for assessing GS impairments indirectly.
Goal(s): To investigate whether GS function changes during aging.
Approach: Four MRI-derived GS indices were combined to quantitative volume fraction of perivascular spaces(PVS), diffusivity along perivascular spaces(ALPS), free water in white matter skeleton(FW in WMs) and choroid plexus volume(Chp).
Results: Our preliminary findings suggested that MRI-derived GS indices change with age.
Impact: These findings may provide new evidence for the influence of GS function on aging and many other neurodegenerative disease in clinical practice.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords