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Abstract #4579

A preliminary study of MRI-Derived Glymphatic System indices in early normal elderly people

Mingming Huang1, Xinyue Lyu1, Yi Yin1, Peng Wu2, and Bo Gao1
1Department of Radiology, Affiliated Hospital of Guizhou Medical University, Guiyang, China, 2Philips Healthcare China, Shanghai, China

Synopsis

Keywords: Aging, Aging, Glymphatic system

Motivation: Glymphatic system(GS), as a brain waste clearance system, has been implicated in many neurodegenerative diseases . However, evidence is limited in a normal ageing population. Indicators based on magnetic resonance imaging (MRI) are the most promising methods for assessing GS impairments indirectly.

Goal(s): To investigate whether GS function changes during aging.

Approach: Four MRI-derived GS indices were combined to quantitative volume fraction of perivascular spaces(PVS), diffusivity along perivascular spaces(ALPS), free water in white matter skeleton(FW in WMs) and choroid plexus volume(Chp).

Results: Our preliminary findings suggested that MRI-derived GS indices change with age.

Impact: These findings may provide new evidence for the influence of GS function on aging and many other neurodegenerative disease in clinical practice.

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