Keywords: Alzheimer's Disease, Alzheimer's Disease
Motivation: Interaction of Alzheimer’s Disease (AD) pathology and vascular comorbidities is difficult to study in humans due to slow course of AD1 and high interpatient heterogeneity2,3. Therefore, experimental AD models with vascular comorbidities are needed with sensitive and translational imaging assays.
Goal(s): Use pCASL to establish an assay of hippocampal neurovascular compromise and its sensitivity to AD with vascular comorbidities.
Approach: TgF344-AD rats were given 3 months ad lib access to high carbohydrate, high fat (HCHF) food. Hippocampal functional hyperemia in response to somatosensation was assessed using pCASL-MRI.
Results: AD pathology induced hippocampal vascular and neuronal dysfunction; whereas HCHF prevented neurovascular impairments.
Impact: We established an assay of hippocampal neurovascular function for studying the sequelae of AD and its vascular comorbidities that is of high translational potential given limited aging/neurodegeneration dependent effects on somatosensation and ease of delivering somatosensory stimuli.
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