Meeting Banner
Abstract #4582

Perfusion Imaging via Pseudo Continuous Arterial Spin Labeling in Transgenic Rat Model of Alzheimer’s Disease on High Carbohydrate High Fat Diet

Dustin Velasco Almanza1,2, Margaret Koletar2, Greg Stanisz1,2, JoAnne McLaurin3, and Bojana Stefanovic1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, 3Biological Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: Interaction of Alzheimer’s Disease (AD) pathology and vascular comorbidities is difficult to study in humans due to slow course of AD1 and high interpatient heterogeneity2,3. Therefore, experimental AD models with vascular comorbidities are needed with sensitive and translational imaging assays.

Goal(s): Use pCASL to establish an assay of hippocampal neurovascular compromise and its sensitivity to AD with vascular comorbidities.

Approach: TgF344-AD rats were given 3 months ad lib access to high carbohydrate, high fat (HCHF) food. Hippocampal functional hyperemia in response to somatosensation was assessed using pCASL-MRI.

Results: AD pathology induced hippocampal vascular and neuronal dysfunction; whereas HCHF prevented neurovascular impairments.

Impact: We established an assay of hippocampal neurovascular function for studying the sequelae of AD and its vascular comorbidities that is of high translational potential given limited aging/neurodegeneration dependent effects on somatosensation and ease of delivering somatosensory stimuli.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords