Abstract #4594
Vendor-Neutral, Free-Breathing Fat Quantification Demonstrates Low Bias and High Reproducibility Across Centers at 0.55T, 1.5T, and 3T
Jiayi Tang1,2, Daiki Tamada2, Shohei Fujita3,4, Pengcheng Xu3,4,5, Christopher Keen6,7, Imam Ahmed Shaik8, Eugene Milshteyn9, Seonghwan Yee4,10, Andrew J Ellison11, David Rutkowski12, Jean H Brittain12, William A Grissom13, Maxim Zaitsev14, Scott B Reeder1,2,15,16,17, Yogesh Rathi8, Yun Jiang6,7, Berkin Bilgic3,4, Jon-Fredrik Nielsen18, and Diego Hernando1,2
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4Radiology, Harvard Medical School, Boston, MA, United States, 5State Key Laboratory of Extreme Photonics and Instrumentation, College of Optical Science and Engineering, Zhejiang University, Zhejiang, China, 6Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 7Radiology, University of Michigan, Ann Arbor, MI, United States, 8Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 9GE HealthCare, Boston, MA, United States, 10Radiology, Massachusetts General Hospital, Boston, MA, United States, 11Biomedical Imaging Center, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA, United States, 12Calimetrix, LLC, Madison, WI, United States, 13Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 14Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Freiburg, Germany, 15Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 16Medicine, University of Wisconsin-Madison, Madison, WI, United States, 17Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States, 18Functional MRI Laboratory, Department of Radiology, University of Michigan, Ann Arbor, MI, United States
Synopsis
Keywords: Quantitative Imaging, Fat and Fat/Water Separation, Validation, reproducibility, cross-vendor
Motivation: Flip-angle modulation (FAM) for motion-robust fat quantification was previously implemented in the vendor-neutral platform Pulseq and demonstrated in two vendors at 3T only. Validation of FAM in additional vendors and field strengths is needed.
Goal(s): Benchmark the quantitative bias and reproducibility of Pulseq-FAM across sites, systems, vendors, and field strengths, relative to product 3D-CSE and vendor-platform FAM.
Approach: Phantom study at four sites with three vendors at 0.55T, 1.5T, and 3T; in vivo free-breathing feasibility evaluated where possible.
Results: Pulseq-FAM shows low bias and similar or improved reproducibility compared to 3D-CSE, and free-breathing feasibility in all field strengths and vendors.
Impact: The strong performance of Pulseq-FAM may enable broader access to free-breathing fat quantification in more vendors and systems. Pulseq-FAM may be used in future studies, such as multi-center clinical trials, which desire harmonization of sequences.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
