Meeting Banner
Abstract #4634

Optimizing Repeatability of RBC Signal Oscillation Measures from Hyperpolarized 129Xe MRI

Ivina Mali1, Bradie Frizzell1, Steven Haworth1, and Peter Niedbalski1
1Internal Medicine, University of Kansas Medical Center, Kansas City, KS, United States

Synopsis

Keywords: Lung, Hyperpolarized MR (Gas), Oscillation Imaging

Motivation: Hyperpolarized 129Xe MRI (Xe-MRI) RBC signal oscillation imaging is a technique in development for assessing microvascular function. Optimal methods for generating oscillation images have not been established.

Goal(s): Using repeatability as a primary outcome, we aim to optimize Xe-MRI oscillation imaging in pulmonary arterial hypertension and scleroderma patients.

Approach: Patients were imaged twice within 10 minutes using Xe-MRI gas exchange imaging. Different oscillation imaging strategies were employed, and the repeatability of each was assessed.

Results: Global measures of oscillation amplitude showed repeatability similar to standard gas exchange measures. Image-based measures showed weaker repeatability demonstrating a need for additional development of the technique.

Impact: Hyperpolarized 129Xe oscillation imaging is a noninvasive technique to assess pulmonary microvascular function. By optimizing the technique for repeatability, it has potential to provide a new means to interrogate pulmonary vascular diseases.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords