Keywords: Lung, Hyperpolarized MR (Gas), Oscillation Imaging
Motivation: Hyperpolarized 129Xe MRI (Xe-MRI) RBC signal oscillation imaging is a technique in development for assessing microvascular function. Optimal methods for generating oscillation images have not been established.
Goal(s): Using repeatability as a primary outcome, we aim to optimize Xe-MRI oscillation imaging in pulmonary arterial hypertension and scleroderma patients.
Approach: Patients were imaged twice within 10 minutes using Xe-MRI gas exchange imaging. Different oscillation imaging strategies were employed, and the repeatability of each was assessed.
Results: Global measures of oscillation amplitude showed repeatability similar to standard gas exchange measures. Image-based measures showed weaker repeatability demonstrating a need for additional development of the technique.
Impact: Hyperpolarized 129Xe oscillation imaging is a noninvasive technique to assess pulmonary microvascular function. By optimizing the technique for repeatability, it has potential to provide a new means to interrogate pulmonary vascular diseases.
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