Keywords: Hyperpolarized MR (Gas), Spectroscopy, CSSR
Motivation: Chemical shift saturation recovery (CSSR) is a useful tool for measuring pulmonary gas exchange, but lacks regional information and error quantification.
Goal(s): To perform CSSR spectroscopy and imaging with an improved analysis pipeline in humans.
Approach: CSSR spectroscopy was performed in eight healthy volunteers and two systemic sclerosis patients. A simultaneous gas-phase/dissolved-phase 129Xe 2D gradient echo sequence was used for CSSR imaging in three healthy volunteers. Spectroscopy and imaging data were fitted to the Patz model using bootstrapping to estimate parameter uncertainties.
Results: The mean error on the alveolar septal thickness (from spectroscopy) was 10%. The CSSR imaging maps agreed quantitatively with spectroscopy.
Impact: Error quantification of CSSR parameters is important for clinical utility and interpretation. Dynamic CSSR gas uptake imaging allows for regional quantification of alveolar septal thickness, which could help identify fibrosis in heterogeneous lung disease.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords