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Abstract #4640

Hyperpolarized xenon-129 phase-contrast velocimetry in an inhaler spacer and the upper airways using direction-specific aliasing velocities

Jimmy Ball1, Guilhem Collier1, Neil J Stewart1, Ryan Munro1, Graham Norquay1, Heather Elphick2, and Jim M Wild1
1POLARIS, Division of Clinical Medicine, School of Medicine & Population Health, University of Sheffield, Sheffield, United Kingdom, 2Sheffield Children’s NHS Foundation Trust, Sheffield, United Kingdom

Synopsis

Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas), xenon-129, phase-contrast, velocimetry, inhaler

Motivation: Understanding gas flow dynamics in the airways is crucial for developing inhaled therapies and treatment for airways diseases.

Goal(s): To measure gas velocities within the upper airways and within an aerosol inhaler spacer.

Approach: 3D phase contrast velocity MRI with hyperpolarized xenon-129 using the 4-point Hadamard interleave method with spiral readout was used. The aliasing velocity was set at different values for each direction to improve dynamic range matching to expected velocities.

Results: Measurement of gas flow patterns in an inhaler spacer as well as in the upper airways in vivo was feasible.

Impact: The results demonstrate the feasibility of phase-contrast velocimetry MRI of inhaled xenon-129 within an inhaler spacer and the upper airways. This will improve validation of computational fluid dynamics to improve inhaled therapy delivery and understanding of upper airways diseases.

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