Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas), xenon-129, phase-contrast, velocimetry, inhaler
Motivation: Understanding gas flow dynamics in the airways is crucial for developing inhaled therapies and treatment for airways diseases.
Goal(s): To measure gas velocities within the upper airways and within an aerosol inhaler spacer.
Approach: 3D phase contrast velocity MRI with hyperpolarized xenon-129 using the 4-point Hadamard interleave method with spiral readout was used. The aliasing velocity was set at different values for each direction to improve dynamic range matching to expected velocities.
Results: Measurement of gas flow patterns in an inhaler spacer as well as in the upper airways in vivo was feasible.
Impact: The results demonstrate the feasibility of phase-contrast velocimetry MRI of inhaled xenon-129 within an inhaler spacer and the upper airways. This will improve validation of computational fluid dynamics to improve inhaled therapy delivery and understanding of upper airways diseases.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords