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Abstract #4647

Hyperpolarized 129Xe Gas Exchange MRS in Mice: Impact of Heart Rate, Ventilation Pressure, and a Paralytic on Cardiogenic Signal Oscillations

Mariah L Costa1,2, Elizabeth M Fugate3, Stephanie A Soderlund1, Neelakshi Chatterjee4,5, Diana M Lindquist3, and Zackary Cleveland1,2,3
1Center for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 3Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 4Department of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 5Department of Biostatistics, Health Informatics and Data Science, College of Medicine, University of Cincinnati, Cincinnati, OH, United States

Synopsis

Keywords: Hyperpolarized MR (Gas), Preclinical, 129Xe, xenon, spectroscopy

Motivation: Upon dissolution into pulmonary tissues, hyperpolarized 129Xe shifts frequency, providing a window into gas-exchange dynamics. Because mice lack a unique RBC peak, the feasibility of harnessing this novel contrast has not yet been investigated.

Goal(s): To demonstrate dissolved 129Xe cardiogenic oscillations in mice for the first time.

Approach: 129Xe magnetic resonance spectroscopy was applied under a range of anesthesia, ventilation, and heart rate conditions to establish a normal physiological baseline.

Results: Oscillations amplitude is strongly correlated with heart rate and sensitive to capillary hemodynamics. With proper animal handling, 129Xe MRS represents a promising method to assess cardiopulmonary pathophysiology in mouse models.

Impact: 129Xe dissolved into tissue displays one peak in mouse lungs. Despite lacking a unique RBC peak, cardiogenic oscillations are observed via MRS. Oscillation amplitude is sensitive to lung hemodynamics and represents a promising means to noninvasively assess pathology in mice.

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Abstract

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