Meeting Banner
Abstract #4649

Increased infusion times of hyperpolarized pyruvate in D2O maintain hyperpolarized lactate generation and approach steady state metabolism

Paola Porcari1,2, Thasin Peyear1,2,3, Saket Patel1,2, Marjan Berishaj1,2, Vesselin Miloushev 1, and Kayvan R Keshari1,2,3
1Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 3Weill Cornell Medical College, New York, NY, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), Data Acquisition, Non‐Proton, Simulation/Validation Simulations, Small Animals, Spectroscopy

Motivation: In vivo hyperpolarized 13C MRI currently requires rapid injection of 13C-labeled probes due to the short T1-dependent lifespans of hyperpolarized substrates, limiting the acquisition window.

Goal(s): Determine how to extend the short acquisition window to enhance the visualization metabolic conversions in vivo.

Approach: We used D2O as dissolution solvent to elongate the T1 of [1-13C]pyruvate and explored prolonged infusion times in the murine brain.

Results: Increased bolus infusion duration resulted in a significant increase in the duration of hyperpolarized [1-13C]pyruvate and [1-13C]lactate

Impact: The combination of [1-13C]pyruvate in D2O, with elongated T1, and increasing injection times demonstrated an extended hyperpolarized steady level for both [1-13C]pyruvate and [1-13C]lactate in a mouse brain, leading to a more robust metabolic imaging with straightforward clinical application.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords