Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), Data Acquisition, Non‐Proton, Simulation/Validation Simulations, Small Animals, Spectroscopy
Motivation: In vivo hyperpolarized 13C MRI currently requires rapid injection of 13C-labeled probes due to the short T1-dependent lifespans of hyperpolarized substrates, limiting the acquisition window.
Goal(s): Determine how to extend the short acquisition window to enhance the visualization metabolic conversions in vivo.
Approach: We used D2O as dissolution solvent to elongate the T1 of [1-13C]pyruvate and explored prolonged infusion times in the murine brain.
Results: Increased bolus infusion duration resulted in a significant increase in the duration of hyperpolarized [1-13C]pyruvate and [1-13C]lactate
Impact: The combination of [1-13C]pyruvate in D2O, with elongated T1, and increasing injection times demonstrated an extended hyperpolarized steady level for both [1-13C]pyruvate and [1-13C]lactate in a mouse brain, leading to a more robust metabolic imaging with straightforward clinical application.
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