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Abstract #4651

Initial Experiences with Hyperpolarized [1-13C] Pyruvate MRI In Hepatocellular Carcinoma Patients

Uffe Kjærgaard1,2, Nikolaj Bøgh1, Malene Aastrup1, Mattias Hedegaard Kristensen1, Nichlas Vous Christensen1, Kim Sivesgaard3, Steffen Ringgaard1, Lotte Bonde Bertelsen1, Esben Søvsø Szocska Hansen1, Henning Grønbæk4, Gerda Elisabeth Villadsen4, and Christoffer Laustsen1
1The MR-Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark, 2Department of Surgery, Aarhus University Hospital, Aarhus University, Aarhus N, Denmark, 3Department of Radiology, Aarhus University Hospital, Aarhus University, Aarhus N, Denmark, 4Department of Hepatology and Gastroenterology, Aarhus University Hospital, Denmark, Aarhus University, Aarhus N, Denmark

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Metabolism, Cancer, Hepatocellular carcinoma

Motivation: To offer patients curative treatment for hepatocellular carcinoma (HCC) it is crucial to make the diagnosis as early as possible. The sensitivity for diagnosis of HCC smaller than 1 cm with traditionally MRI is low.

Goal(s): We aim to investigate if adding hyperpolarized [1-13C] pyruvate to the conventional MRI exam can improve the diagnosis and aggressiveness assessment of HCC by characterizing tumor metabolism.

Approach: We used hyperpolarized [1-13C] pyruvate MRI to assess tumor metabolism in patients with HCC.

Results: Results show altered metabolism in confirmed HCC and interestingly a case of glutaminase synthase positive HCC shows increased alanine/pyruvate compared to non-tumor liver.

Impact: Hyperpolarized MRI in patients with HCC is feasible and may be used to detect early HCC and might characterize glutaminase synthase positive tumors non-invasively by increased alanine production.

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Abstract

Keywords