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Abstract #4655

Early detection of diabetic nephropathy using compartment-specific hyperpolarized 13C metabolic readouts

Cornelius von Morze1, Ashley Shaw1, and Tyler Blazey1
1Mallinckrodt Institute of Radiology, Washington University, St Louis, MO, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)

Motivation: There is a pressing need for new non-invasive markers of diabetic kidney disease.

Goal(s): Our goal is to demonstrate that hyperpolarized (HP) 13C MRI can detect early metabolic indicators of diabetic nephropathy.

Approach: We conducted serial HP 13C imaging studies of rats with uncontrolled diabetes using co-HP [1-13C]pyruvate and [1,3-13C2]acetoacetate for cellular compartment-specific metabolic measurements, in comparison with conventional serum markers of kidney function.

Results: Metabolic conversions of HP substrates showed large, compartment-specific shifts in diabetic kidney over time, as compared with conventional serum markers. These metabolic changes indicate a progressive deficit of oxygen metabolism in diabetic kidney.

Impact: Precise metabolic measurements obtained non-invasively by HP 13C MRI with multiple co-HP metabolic substrates, whose activities are localized to distinct cellular compartments, could enable early detection of diabetic kidney damage.

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