Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas), Transcriptomics
Motivation: Hyperpolarized 13C MRI (HP 13C-MRI) imaging of the whole-brain provides contrast that is proportional to underlying metabolic processes. Consistent patterns of regional HP 13C-MRI metabolite signal distribution in the healthy human brain have been observed, but it's not clear what drives these patterns.
Goal(s): We hypothesized that regional patterns of HP 13C-MRI signal distribution would correspond to cell-type distributions in the brain.
Approach: Gene data from a database of post-mortem brains was correlated with HP 13C-MRI signal (n = 43) through a statistically robust transcriptomic analysis.
Results: HP 13C-bicarbonate signal, an indirect marker of oxidative metabolism, correlated with excitatory neuronal cell populations.
Impact: We found that there was a pattern of neuron cell distribution in the healthy brain that correlates with hyperpolarized 13C-signal topography. These results provide a better understanding of the physiology driving hyperpolarized 13C-signal patterns in healthy human brains.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords