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Abstract #4672

Glymphatic system impairment causes clinical disability through the accumulation of tissue damage in multiple sclerosis

Zhuo Wang1, Xia Xu2, Wenjing Ren2, Jing Zhang2, and Kai Ai3
1The Second Hospital & Clinical Medical School, Lanzhou University, Lan Zhou, China, 2The Second Hospital of Lanzhou University, Lanzhou, China, 3Department of Clinical and Technical Support, Philips Healthcare, Xi’an, China

Synopsis

Keywords: DWI/DTI/DKI, Multiple Sclerosis, glymphatic system, along perivascular space index, clinical disability, lesion burden

Motivation: The role of the glymphatic system in multiple sclerosis (MS)-related disability has not been thoroughly investigated. Diffusion-tensor image analysis along the perivascular space (DTI-ALPS) offers a noninvasive method.

Goal(s): To investigate the association between glymphatic function and disability in MS and analyze whether it was mediated by the tissue damage accumulation.

Approach: 59 MS patients and 44 healthy controls were enrolled. DTI-ALPS index was calculated. Correlations between DTI-ALPS and tissue damage accumulation and clinical disability were analyzed.

Results: The glymphatic system is impaired in MS. The impact of glymphatic impairment on disability is mediated by the tissue damage accumulation.

Impact: The impact of glymphatic impairment on disability is mediated by the tissue damage accumulation, indicating a pathological mechanism for MS-related disability.

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