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Abstract #4678

Inter-scanner reproducibility of DTI parameters in WM tracts using TractFinder across three MRI scanners of the same type

Agnieszka Sierhej1,2,3, Matt G Hall2, Nadia A.S Smith4, Kiran K Seunarine1,3, Jonathan D Clayden1, Marta M Correia5, C. John Evans6, and Chris A Clark1,3
1UCL GOS Institute of Child Health, University College London, London, United Kingdom, 2National Physical Laboratory, Teddington, United Kingdom, 3Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 4TÜV SÜD UK, Warrington, United Kingdom, 5MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom, 6CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom

Synopsis

Keywords: DWI/DTI/DKI, Quantitative Imaging, Reproducibility, Brain, White Matter

Motivation: Quantitative neuroimaging studies often require large datasets, and it is common to collect the data using multiple scanners.

Goal(s): However, the inter-site reproducibility of DTI parameters should be determined before embarking on a multi-centre study.

Approach: We used TractFinder to assess the reproducibility of DTI parameters in clinically relevant WM tracts across three scanners of the same type (Siemens Prisma 3T).

Results: Our results provide evidence that FA and MD have excellent reproducibility across scanners of the same type when the acquisition scheme and pre-processing pipeline are identical, and WM tract ROIs are automatically segmented.

Impact: DTI-derived FA and MD have excellent reproducibility (ICC ≥ 0.95) across three scanners of the same type when WM tract ROIs are automatically segmented. This allows neuroimaging studies to use multi-centre DTI data with confidence.

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