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Abstract #4680

Cholinergic white matter pathway in Parkinson's disease based on multimodal magnetic resonance imaging technology

Lina Huang1, Xiaolu Li1, Shuting Bu1, Mengwan Zhao1, Yueluan Jiang2, and Guoguang Fan1
1the first hospital of China medical University, Shenyang, China, 2MR Research Collaboration, Siemens Healthineers, Beijing, China

Synopsis

Keywords: DWI/DTI/DKI, Parkinson's Disease

Motivation: The identification and treatment of PD present formidable challenges due to the absence of objective and specific indicators.

Goal(s): Our goal is to explore the potential of multimodal MRI in identifying and treating PD-MCI, providing a more accurate and objective assessment for these patients.

Approach: DTI and fMRI sequences are used to quantitatively assess brain fibers and networks. Through partial least squares and ROC analysis, we investigate the potential of multimodal MRI in differentiating PD-MCI.

Results: Multimodal magnetic resonance imaging provides objective and quantifiable markers for the early differentiation of PD-MCI and the evaluation of cholinergic drug treatment.

Impact: Multimodal MRI provides reliable, objective markers that improve early differentiation of PD-MCI, enabling earlier, more precise interventions and potentially enhancing patient outcomes while reducing healthcare burdens.

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