Keywords: Osteoarthritis, Quantitative Imaging
Motivation: Bi-exponential (BE) T2 and T1ρ mapping show promise for early knee osteoarthritis (OA) detection, but long scan times and low SNR limit their usage.
Goal(s): Use our learned pulse sequence (L-MPGRE) for T2 and T1ρ mapping and evaluate the discrimination between OA patients and healthy subjects (HS).
Approach: We used the L-MPGRE sequence on 5 OA patients (KL=1 or 2) and 6 HS to measure T2 and T1ρ values, and compute effect-size and p-values.
Results: T1ρ value is better at discriminating early OA from HS. However, successful differentiation with BE models depends on using linear discriminant analysis and proper threshold of BE components.
Impact: Learned pulse sequences are useful for early OA detection, with T1ρ outperforming T2 mapping. Results indicate that BE models can be advantageous if linear discriminant analysis and the proper threshold are used.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords