Abstract #4690

Quantification of Infrapatellar fat pad fibrosis using MRI-derived PDFF: A pathology-controlled study

Beibei Zhou¹, Jinling Wu¹, Tianyun Zhao², Qingling Yu¹, Kexin Jiang¹, Xinru Zhang¹, Qingzhu Wei³, Rongkai Zhang⁴, Hang Fang Fang⁴, Hongbo Zhang⁵, Yanjun Chen¹, Xiaodong Zhang¹, and Chuan Huang⁶

¹Department of Radiology,The Third Affiliated Hospital, Southern Medical, Guang zhou, China, ²Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, Stony Brook, NY, United States, ³Department of Pathology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510515, China, Guangzhou, China, ⁴Department of Joint Surgery, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China, ⁵Department of Radiology, The Seventh Afﬁliated Hospital, Sun Yat-sen University, Shenzhen, China, ⁶Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, Emory University, GA, United States

Synopsis

Keywords: Osteoarthritis, Fat and Fat/Water Separation, Infrapatellar fat pad

Motivation: Fibrosis of the infrapatellar fat pad (IPFP) impacts knee osteoarthritis (KOA) progression ^[1]. Accurate assessment of IPFP fibrosis aids early intervention and treatment.

Goal(s): To evaluate the diagnostic efficacy of proton density fat fraction (PDFF) and T2* measurements using mDixon-Quant technology in assessing IPFP fibrosis in KOA.

Approach: We employed mDixon-Quant sequence to measure PDFF and T2*of IPFP, and evaluated correlations of the parameters with pathology-derived IPFP fibrosis degree and diagnostic efficacy.

Results: PDFF and T2* measurements were strongly correlated with IPFP fibrosis and showed good diagnostic performance for IPFP fibrosis.

Impact: PDFF and T2* measurements based on mDixon technology provide a non-invasive and quantitative assessment of IPFP fibrosis, especially PDFF.

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