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Abstract #4694

Exploratory Investigation on Bone-Muscle-Cartilage Relationships in Knee Osteoarthritis

Francesca Belibi1, Yael Vainberg1, Garry Gold1, Feliks Kogan1, and Ananya Goyal1
1Radiology, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Osteoarthritis, PET/MR, Cartilage, Bone

Motivation: Osteoarthritis is a multifaceted disease and while the relationships between bone and cartilage have been well researched, inclusion of muscle in this relationship is less researched.

Goal(s): The goal is to determine if high muscle fat fraction and lower muscle volume will correlate with increased subchondral bone remodeling and cartilage loss and matrix changes.

Approach: 12 women (6 w/OA) underwent two bilateral [18F]NaF PET/MRI knee scans before and after exercise from which muscle, bone, and cartilage were segmented and analyzed.

Results: Results show correlations between muscle, bone, and cartilage variables for some muscle-bone/cartilage regions.

Impact: More studies analyzing the muscle-bone-cartilage relationships can further expand on this theory and help in understanding the whole joint nature of OA.

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