Keywords: Parkinson's Disease, Parkinson's Disease, Template, PD, NM-MRI, Neuromelanin, SMwI, SNpc, Registration
Motivation: Atlas-based study is an important tool in medical imaging. However, for NM-MRI and SMwI, there is no developed public template, making atlas-based research difficult.
Goal(s): The purpose of this work was to develop T1-weighted (T1w), NM-MRI, and SMwI templates to allow atlas-based multimodal analysis for slab images.
Approach: We utilized iterative multimodal template creation approaches and cropped the image to the periphery of the ROI that is least affected by the capture angle.
Results: The proposed templates achieved higher image quality, especially for the Substantia nigra region, and allowed accurate registration across subjects and modalities when compared to previous templates.
Impact: By constructing the high quality template of NM-MRI and SMwI, atlas-based analysis can be used to NM-MRI and SMwI.
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