Keywords: Parkinson's Disease, Analysis/Processing
Motivation: Cognitive impairment (PD-CI) is common in Parkinson’s disease (PD), but reliable diagnostic biomarkers are lacking.
Goal(s): To explore the correlation between gray matter and PD-CI using T1/T2 mapping with MAGiC and identify potential biomarkers.
Approach: We applied the MAGiC technique to investigate T1/T2 mapping in PD patients and correlate it with cognitive performance.
Results: Significant diagnostic value was found, with T1/T2 mapping in the left putamen serving as a potential biomarker for PD-CI.
Impact: This study provides an objective imaging biomarker for cognitive impairment in Parkinson's disease, enhancing early detection and aiding in the development of personalized therapeutic strategies to manage PD-associated cognitive decline more effectively.
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