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Abstract #4705

Correlation between T1/T2 mapping and cognitive impairment in Parkinson's disease based on Magic MRI quantitative imaging technique

Rui Zhang1, Miao Chen1, Lizhi Xie2, Wenjia Wang2, and Gang Zhang1
1Hulunbuir people’s hospital, Hulunbuir, China, 2GE HealthCare, Beijing, China

Synopsis

Keywords: Parkinson's Disease, Analysis/Processing

Motivation: Cognitive impairment (PD-CI) is common in Parkinson’s disease (PD), but reliable diagnostic biomarkers are lacking.

Goal(s): To explore the correlation between gray matter and PD-CI using T1/T2 mapping with MAGiC and identify potential biomarkers.

Approach: We applied the MAGiC technique to investigate T1/T2 mapping in PD patients and correlate it with cognitive performance.

Results: Significant diagnostic value was found, with T1/T2 mapping in the left putamen serving as a potential biomarker for PD-CI.

Impact: This study provides an objective imaging biomarker for cognitive impairment in Parkinson's disease, enhancing early detection and aiding in the development of personalized therapeutic strategies to manage PD-associated cognitive decline more effectively.

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