Abstract #4711

Dorsal Hyperintensity and Iron Deposition Patterns in the Substantia Nigra of Early-Onset Parkinsonism: A 7T MRI Study

Dongning Su¹, Zhijin Zhang¹, Zhe Zhang², Rui Yan¹, Tingyan Yao³, Wanlin Zhu², Ning Wei², Yue Suo², Xinyao Liu², Huiqing Zhao¹, Zhan Wang¹, Huizi Ma¹, Wei Li¹, Yuan Li⁴, Joyce S. T. Lam⁵, Junhong Zhou⁶, Tao Wu¹, Jing Jing², and Tao Feng¹

¹Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ²Tiantan Neuroimaging Center of Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ³Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, China, ⁴MR Research Collaboration Team, Siemens Healthineers, Beijing, China, ⁵Pacific Parkinson’s Research Centre, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, DC, Canada, ⁶Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Roslindale, MA, United States

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, 7T MRI; dorsal nigral hyperintensity; Wilson disease

Motivation: The dorsal nigral hyperintensity (DNH) abnormality is recognized as an imaging characteristic of Parkinson’s disease (PD).

Goal(s): To assess the utility of DNH abnormality in diagnosis of early-onset Parkinsonism using 7T MRI.

Approach: Early-onset PD (EOPD), neurological Wilson’s disease (NWD) with parkinsonism, and health controls were recruited to assess the diagnostic performance of DNH abnormality. All underwent 7T T2*-weighted imaging with R2* mapping and principal component analysis performed.

Results: The DNH abnormality showed high accuracy in differentiating EOPD from health controls and NWD with parkinsonism. EOPD presented predominant iron deposition in the dorsal and posterior substantia nigra.

Impact: The DNH abnormality could aid the diagnosis of EOPD and its differentiation from NWD with parkinsonism. The DNH abnormality may be related to predominant iron deposition in the dorsal and posterior substantia nigra in EOPD.

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