Abstract #4717

Amplified MR assessment of idiopathic Normal Pressure Hydrocephalus Pre-/Post-Shunt Surgery.

Fargol Rezayaraghi¹, Michael A. Williams^2,3, Mehmet Kurt¹, Michael Levitt³, Elisa McGee^2,3, Samantha Holdsworth⁴, Itamar Terem⁵, Dallas Turley⁶, Ann Wilson⁷, Swati Rane⁷, and Jalal B. Andre⁷

¹Mechanical Engineering, University of Washington, Seattle, WA, United States, ²Neurology, University of Washington Medical Center, Seattle, WA, United States, ³Neurological Surgery, University of Washington Medical Center, Seattle, WA, United States, ⁴University of Auckland, Gisborne, New Zealand, ⁵Stanford University, Stanford, CA, United States, ⁶Philips Healthcare, Seattle, WA, United States, ⁷Radiology, University of Washington Medical Center, Seattle, WA, United States

Synopsis

Keywords: Neurofluids, Aging, Normal Pressure Hydrocephalus

Motivation: This study aims to correlate variations in subvoxel displacement magnitudes with ventriculoperitoneal shunt status in patients with normal pressure hydrocephalus (NPH).

Goal(s): We sought to evaluate intracranial voxel displacement as a non-invasive surrogate of intracranial compliance for risk assessment in NPH patients using amplified MRI (aMRI), a clinically feasible, cardiac-gated, cine-based method employing Eulerian video magnification to amplify and characterize subvoxel motion.

Approach: NPH patients clinically necessitating ventriculoperitoneal shunt (VPS) placement underwent aMRI one-week before and 3 months after VPS surgery.

Results: Percentage change in whole brain maximum displacement magnitude pre- and post-shunt surgery was the best predictor of VPS status (p=0.01).

Impact: In this pilot study evaluating normal pressure hydrocephalus patients necessitating ventriculoperitoneal shunt (VPS) surgery, derived amplified MRI metrics correlate with VPS status (p=0.01), and may serve as a novel biomarker in assessing functional VPS status in clinical practice.

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