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Abstract #4722

Choroid Plexus Volume and Perfusion Abnormalities May Explain Pathophysiology and Cognitive Impairment in Cerebral Small Vessel Disease

Dan Luo1, Yongmei Li1, Tianyou Luo1, and Lisha Nie2
1The First Affiliated Hospital of Chongqing Medical University, Chongqing, China, 2GE HealthCare MR Research, Beijing, China

Synopsis

Keywords: Neurofluids, Perfusion, cerebral small vessel disease, choroid plexus, cognition, glymphatic system

Motivation: The choroid plexus (CP) is involved in the pathophysiology of cerebral small vessel disease (CSVD), but its specific imaging and clinical impacts remain unclear.

Goal(s): This study aimed to quantify CP abnormalities and examine their associations with CSVD imaging markers and cognitive function.

Approach: We included 90 CSVD patients and 26 healthy controls. Manual CP segmentation was performed, and normalized CP volume, magnetic susceptibility, and perfusion metrics were measured using T1-weighted imaging, quantitative susceptibility mapping, and arterial spin labeling.

Results: CSVD patients exhibited enlarged CP volume, reduced susceptibility and perfusion, with correlations to disease burden and specific cognitive domains.

Impact: The study reveals CP structural and functional abnormalities as contributors to CSVD-related brain damage and cognitive decline, offering new insights into CSVD pathophysiology. These findings highlight CP-targeted interventions as a potential therapeutic strategy.

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Keywords