Keywords: Neurofluids, Brain Connectivity, Glymphatic System; Medication Overuse Headache; 7T
Motivation: The glymphatic system (GS) and brain function are involoved in Medication overuse headache (MOH) pathophysiology.
Goal(s): To investigate differences in GS and brain function in MOH versus episodic migraine (EM) and healthy controls (HCs), and correlations between GS, brain function, and clinical parameters in MOH.
Approach: We evaluated the analysis along the perivascular space (ALPS) index, mean amplitude of low-frequency fluctuations (mALFF) and regional homogeneity (Reho) in 49 MOH patients, 54 EM patients, and 45 HCs using 7T.
Results: MOH patients showed a lower ALPS index, higher mALFF, and altered FC, with ALPS index correlating with FC, pain degree, and duration in MOH.
Impact: The ALPS index and functional changes may serve as a sensitive neuroimaging biomarker for predicting the progression from EM to MOH. And they may interact with each other in the pathogenesis of patients with MOH, collectively influencing the disease mechanism.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords