Abstract #4732

Correcting the Effects of Patient Bulk Motion on DENSE Measures of Cardiac Induced Brain Displacement

Caroline A. Doctor¹, Leonardo A. Rivera-Rivera^1,2, Laura B. Eisenmenger³, Sterling C. Johnson², and Kevin M. Johnson^1,3,4

¹Department of Medical Physics, University of Wisconsin, Madison, WI, United States, ²Department of Medicine, University of Wisconsin, Madison, WI, United States, ³Department of Radiology, University of Wisconsin, Madison, WI, United States, ⁴Department of Biomedical Engineering, University of Wisconsin, Madison, WI, United States

Synopsis

Keywords: Neurofluids, Neurofluids, Aging, Brain, Blood Vessels, Cardiovascular, Dementia, Flow, Motion Correction, Neuro, Neurodegeneration, Neurofluids, Velocity & Flow

Motivation: Due to sub-millimeter displacement encoding, DENSE scans in the brain are highly sensitive to patient bulk motion.

Goal(s): Our goals were to evaluate both the impact of bulk motion on DENSE scans in the brain, and to what extent we can mitigate the effects of this motion in post-processing.

Approach: 2D DENSE scans were acquired with and without induced motion, at 3 axial slice positions in the brain.

Results: Bulk motion has a significant impact on DENSE displacement measures. However, the motion correction methods implemented effectively corrected for patient bulk motion and demonstrated repeatability in test-retest analysis.

Impact: DENSE scans with and without induced motion were acquired, to evaluate and correct the effects of patient bulk motion. Our motion correction methods were effective in correcting for both rotational and translational bulk motion and demonstrated repeatability in test-retest analysis.

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