Abstract #4734

Investigating the Influence of CSF on Diffusion Characteristics in the Parasagittal Dura

Chun-Han Liao^1,2,3, Yung-Yin Cheng^1,4, Chun-Wen Chen⁵, Chia-Hong Hsieh^1,5, Shin-Lei Peng⁶, Hing-Chiu Chang⁷, Shao-Chieh Lin¹, Ya- Hui Lee⁸, Chao-Chun Lin⁹, Chia-Wei Lin⁹, and Yi-Jui Liu¹⁰

¹Ph.D. program in Electrical and Communication Engineering, Feng Chia University, Taichung, Taiwan, ²Department of Medical Imaging, Yuanlin Christian Hospital, Changhua, Taiwan, ³Department of Medical Imaging, Changhua Christian Hospital, Changhua, Taiwan, ⁴Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, ⁵Department of Radiology, School of Medicine, National Defense Medical Center, Taipei, Taiwan, ⁶Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, ⁷Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁸Department of Medical Imaging, China Medical University Hsinchu Hospital, Hsinchu, Taiwan, ⁹Department of Radiology, China Medical University Hospital, Taichung, Taiwan, ¹⁰Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan

Synopsis

Keywords: Neurofluids, Neurofluids, FLAIR, DWI, Meningeal lymphatics vessels, parasagittal dura, CSF

Motivation: Is ADC in the parasagittal dura influenced by CSF during fast and slow diffusion?

Goal(s): This study aims to utilize DWI to assess the circulatory condition of the parasagittal dura while minimizing CSF contamination, enhancing the accuracy of ADC for a clearer representation of the circulatory status of the parasagittal dura.

Approach: Water diffusion measurements in the parasagittal dura were conducted using DWI with and without the FLAIR technique across low and high b-values.

Results: ADCs in the parasagittal dura measured by FLAIR-DWI were lower than those obtained through nonFLAIR-DWI during slow diffusion but were higher during fast diffusion.

Impact: Given that DWI can be utilized to assess the circulatory condition of the parasagittal dura, our study investigates the influence of CSF on the diffusion of the parasagittal dura using both FLAIR-DWI and conventional DWI across low and high b-values.

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