Keywords: Neurofluids, Neurofluids, Extravascular brain clearance
Motivation: No established method exists to quantify cerebrospinal fluid (CSF) inflow to brain tissue, an important driver of brain waste clearance.
Goal(s): We propose a novel method using dynamic contrast-enhanced MRI after tracer infusion in cisterna magna in rats to quantify CSF inflow to a large section of brain tissue.
Approach: CSF perfusion territory, CSF flow velocity and cross-sectional area in the pial perivascular space of the middle cerebral artery are combined to estimate volumetric CSF inflow and compared with interstitial fluid clearance rates.
Results: Both CSF inflow and interstitial fluid clearance are approximately 0.5 µl·g-1·min-1, similar to lymphatic fluid flow in heart tissue.
Impact: Our novel CSF inflow measurement method underscores a probable connection between brain waste clearance and cerebrospinal fluid inflow. It provides a quantitative platform for future biomarkers in both preclinical and clinical investigations of brain waste clearance and CSF circulation.
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