Abstract #4740

Changes in Cerebrospinal Fluid Dynamics in the Whole Brain with Ultrasound Pulsed Stimulation: A Feasibility Study

Tahira Rafiq¹, Taewon Choi¹, Hyochul Lee^2,3, Roh Eul Yoo^3,4,5, Seung Hong Choi^3,4,5, Jinhyoung Park^1,6, and Jaeseok Park^1,6

¹Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of, ²Interdisciplinary Programs in Cancer Biology Major, Seoul National University Graduate School, Seoul, Korea, Republic of, ³Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, ⁴Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Korea, Republic of, ⁵School of Transdisciplinary Innovations, Seoul National University, Seoul, Korea, Republic of, ⁶Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Synopsis

Keywords: Neurofluids, Focused Ultrasound, Glymphatic System,Cerebrospinal fluid, Contrast-enhanced MRI

Motivation: This study examines changes in cerebrospinal fluid (CSF) dynamics across the brain with low-intensity focused ultrasound (LIFU) applied to the transverse sinus to stimulate CSF flow.

Goal(s): To visualize CSF dynamics across the rat brain following LIFU stimulation using contrast-enhanced MRI (CE-MRI) over a 24-hour period.

Approach: Six SD rats received intrathecal contrast agent (into cisterna magna). CE-MRI scans were performed hourly, with LIFU stimulation during the first four hours (10 mins each). Voxel-wise analysis compared contrast dynamics with and without LIFU.

Results: LIFU stimulation enhanced CSF dynamics, indicated by shorter time-to-peak and higher infusion rates across the brain compared to controls.

Impact: This study highlights enhanced CSF dynamics over the whole brain in rats with the LIFU-induced stimulation, potentially facilitating waste clearance in glymphatic system.

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