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Abstract #4744

Highly-accelerated CSF-STREAM: two-fold faster CSF-mobility and FA measurement in PVS, via Locally Low Rank reconstruction

Maddalena Debiasi1, Matthias J.P. van Osch1, Yiming Dong1,2, and Lydiane Hirschler1,2
1C.J. Gorter MRI Center, Radiology, Leiden UMC, Leiden, Netherlands, 2Shared last authorship, ., Netherlands

Synopsis

Keywords: Neurofluids, High-Field MRI, Glymphatics, Image Reconstruction

Motivation: CSF-STREAM is a high-resolution sequence designed to isolate CSF signal and compute its mobility, from large compartments down to small perivascular spaces. The downside is the long acquisition time.

Goal(s): Halve the CSF-STREAM scan time, without compromising image quality.

Approach: Increase the acceleration factor from 15x to 32x, while maintaining the image quality thanks to a joint reconstruction algorithm.

Results: Scanning time is effectively reduced by half with resulting image quality comparable to the original 15x scan, while minimally impacting CSF-mobility and FA.

Impact: The improvement in acquisition speed makes CSF-STREAM more suitable to fit into scanning protocols including patients. Together with the improvement in the reconstruction, we made CSF-STREAM a powerful, contrast-free sequence to study glymphatics in humans in-vivo.

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