Keywords: Neurofluids, High-Field MRI, Glymphatics, Image Reconstruction
Motivation: CSF-STREAM is a high-resolution sequence designed to isolate CSF signal and compute its mobility, from large compartments down to small perivascular spaces. The downside is the long acquisition time.
Goal(s): Halve the CSF-STREAM scan time, without compromising image quality.
Approach: Increase the acceleration factor from 15x to 32x, while maintaining the image quality thanks to a joint reconstruction algorithm.
Results: Scanning time is effectively reduced by half with resulting image quality comparable to the original 15x scan, while minimally impacting CSF-mobility and FA.
Impact: The improvement in acquisition speed makes CSF-STREAM more suitable to fit into scanning protocols including patients. Together with the improvement in the reconstruction, we made CSF-STREAM a powerful, contrast-free sequence to study glymphatics in humans in-vivo.
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