Abstract #4750

Fast, Motion-Robust, Multi-Contrast MRI of the Human Brain using Triplanar 2D EPI acquisitions and Super-Resolution Reconstruction

Michael Adam^1,2, Beata Bachrátá^3,4, Wolfang Bogner^1,2, and Simon Daniel Robinson^1,2

¹High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK), Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Department of Medical Engineering, Carinthia University of Applied Sciences, Klagenfurt, Austria, ⁴Karl Landsteiner Institute for Clinical Molecular MR in Musculoskeletal Imaging, Vienna, Austria

Synopsis

Keywords: Multi-Contrast, Acquisition Methods, Fast, motion-robust, EPI

Motivation: Isotropic T2*-weighted images can be generated from three low resolution 2D EPI datasets acquired in orthogonal planes and reconstructed with a super-resolution (SR) approach. This ‘NATIve’ method offers a potential basis for a comprehensive imaging examination for patients who cannot lie still for long periods.

Goal(s): To extend the NATIVE approach to generate multi-contrast images of the brain.

Approach: 2D EPI with a range of magnetisation preparations were acquired and reconstructed using two SR algorithms.

Results: T1-weighted, T2-weighted, T2*-weighted and FLAIR images of the brain were generated. Resolution was increased compared to the original method using an improved super-resolution algorithm.

Impact: The inability of many patients to lie still during MRI leads to motion-corrupted images. Fast imaging with multiple contrasts could make a significant contribution to imaging patients with diseases which make it difficult to stay still, such as Parkinson's disease.

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