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Abstract #4755

50 Years after Relaxometry: The Performance of Three Quantitative MRI Methodologies in the Real World

Gaoyang Zhao1, Jialiang Teng1, Lina Zhang1, Yanglei Wu2, Mengzhu Wang2, Mathias Nittka3, Yuncai Ran1, Feng Chen4, Hongwei Zheng1, Yong Zhang1, and Jingliang Cheng1
1Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2MR Research Collaboration, Siemens Healthineers, Beijing, China, 3MR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany, 4Department of Radiology, Hainan General Hospital, Haikou, China

Synopsis

Keywords: Relaxometry, Quantitative Imaging, MR Fingerprinting, Synthetic MR

Motivation: Clinical applications of T1/T2 relaxometry are hindered by methodological inconsistencies, limiting clinical translation.

Goal(s): This study systematically compares three quantitative MRI methodologies that are currently more commonly used in clinical practice to clarify their stability and resolve uncertainties in method selection.

Approach: Using standardized MRI phantoms (ISMRM/NIST) and healthy volunteers undergoing brain scans, we assessed T1 and T2 values with each methodology.

Results: Significant variability in T1/T2 values was found across three methodologies, and population feature distributions also differed, underscoring the need for consistent imaging protocols to ensure comparability in relaxometry studies.

Impact: This study highlights the need for standardized relaxometry protocols or rigorous data screening to minimize bias, enabling reliable T1/T2 imaging analysis and advancing clinical translation.

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