Keywords: Relaxometry, Quantitative Imaging, MR Fingerprinting, Synthetic MR
Motivation: Clinical applications of T1/T2 relaxometry are hindered by methodological inconsistencies, limiting clinical translation.
Goal(s): This study systematically compares three quantitative MRI methodologies that are currently more commonly used in clinical practice to clarify their stability and resolve uncertainties in method selection.
Approach: Using standardized MRI phantoms (ISMRM/NIST) and healthy volunteers undergoing brain scans, we assessed T1 and T2 values with each methodology.
Results: Significant variability in T1/T2 values was found across three methodologies, and population feature distributions also differed, underscoring the need for consistent imaging protocols to ensure comparability in relaxometry studies.
Impact: This study highlights the need for standardized relaxometry protocols or rigorous data screening to minimize bias, enabling reliable T1/T2 imaging analysis and advancing clinical translation.
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