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Abstract #4757

Technical Foundation of Magnetic Resonance Elastography in the Peripheral Nervous System

Hannah Fels-Palesandro1, Gabrielle Mangin2, Inas H Faras3,4, Sabine Heiland1, Martin Bendszus1, Katharina Schregel1, and Ralph Sinkus2,5
1Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, 2UMRS1148 - Laboratory for Vascular Translational Science, INSERM, Paris, France, 3Department of Structural Mechanics, University of Granada, Granada, Spain, 4Institito de Investigación Biosanitaria, ibs. GRANADA, Granada, Spain, 5School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom

Synopsis

Keywords: Elastography, Elastography, Nerves, Nervous System

Motivation: Imaging of peripheral nerves becomes increasingly important. 2D-US-Elastography has delivered first interesting yet possibly biased results regarding altered biomechanics in nerve disorders.

Goal(s): To test the feasibility of MRE to examine peripheral nerves and obtain reliable, unbiased results.

Approach: An agar gel nerve phantom and sciatic nerve specimen were examined with 2D-MRE in optimized conditions (planar shear wave propagation). To verify the correctness of the obtained results, 3D-MRE of the phantom’s components was performed and the setup was numerically simulated.

Results: In optimized conditions 2D-MRE delivered correct biomechanical parameters for the nerve phantom and gave a first estimate of nerval stiffness in specimen.

Impact: MRE is feasible in peripheral nerves and 2D-MRE delivers correct biomechanical information in optimized in-vitro examination conditions, thus serving as built-up for optimization of 3D-MRE in peripheral nerves and clinical translation.

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