Abstract #4759

The severity of brain changes measured by MR fingerprinting in patients with White Matter Hyperintensities

Gaoyang Zhao¹, Lin Sun², Mengzhu Wang³, Mathias Nittka⁴, Jingliang Cheng¹, and Yong Zhang¹

¹Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²Department of Radiology, Luoyang Zhenggu Hospital of Henan Province, Zhengzhou, China, ³MR Research Collaboration, Siemens Healthineers, Beijing, China, ⁴MR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany

Synopsis

Keywords: Relaxometry, MR Fingerprinting, Neurodegeneration; Quantitative Imaging

Motivation: Limited by inefficient and subjective diagnostics for brain white matter abnormalities, we sought to enhance clinical assessments by validating MR Fingerprinting's efficiency in quantifying these issues.

Goal(s): To determine if MRF accurately quantifies brain white matter abnormalities in routine clinical settings.

Approach: Used MRF to measure T₁ and T₂ values in 87 patients with white matter abnormalities, comparing them with the performance of T₂ FLAIR images

Results: Significant differences were observed in relaxation times between white matter inside and outside T₂ FLAIR high signal areas, indicating MRF's potential for accurate quantifiable diagnosis of brain white matter abnormalities.

Impact: Our study's outcomes can enhance clinical assessments of brain white matter abnormalities. This impacts patients, healthcare providers, and researchers by allowing for more efficient and accurate diagnosis and understanding of previously challenging issues, thereby improving patient care and outcomes.

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