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Abstract #4761

Investigating spatial distribution of metabolite diffusion using diffusion-weighted chemical exchange saturation transfer

Yujin Jung1, Jaeseok Park2, Seong-Gi Kim2, and Sung-Hong Park1
1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of, 2Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Synopsis

Keywords: CEST / APT / NOE, High-Field MRI, Metabolite diffusion

Motivation: Metabolite diffusion provides information on distinctive intracellular environments compared to water diffusion. Conventional diffusion-weighted MRS (DW-MRS) is a useful tool, but it lacks spatial information.

Goal(s): We aimed to investigate the spatial distribution of metabolite diffusion in the human brain using diffusion-weighted CEST (DW-CEST).

Approach: We performed DW-CEST on a phantom and five human subjects, and then compared ADCs of amide and water in brain tissues.

Results: The amide-weighted ADC was 0.2 × 10-3 mm2/s and ~7.5 times smaller than water ADC in the brain. The gray matter / white matter ratio was ~0.8 for the amide-weighted ADC.

Impact: Analysis on amide-weighted ADC showed comparable results to findings in DW-MRS studies with more spatial information. This suggests that DW-CEST has the potential to examine metabolite diffusion with better spatial resolution than DW-MRS.

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