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Abstract #4771

Repeatability of Absolute vs Relative Cerebral Blood Flow and Arterial Transit Time for Single-Delay and Multi-Delay Arterial Spin Labelling

Aisling E Fothergill1,2, David Higgins3, Owen Thomas2,4, David Coope2,5, Ibrahim Djoukhadar2,4, and Laura M Parkes1,2
1Division of Psychology, Communication and Human Neuroscience, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, 2Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Manchester, United Kingdom, 3Philips, Farnborough, United Kingdom, 4Department of Radiology, Salford Royal Northern Care Alliance NHS Foundation Trust, Manchester, United Kingdom, 5Department of Academic Neurological Surgery, Salford Royal Northern Care Alliance NHS Foundation Trust, Manchester, United Kingdom

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling, Repeatability, Neuro, Perfusion

Motivation: Arterial Spin Labelling (ASL) is non-invasive making it valuable for longitudinal imaging, therefore knowing the repeatability is crucial.

Goal(s): Compare repeatability of single-delay ASL (SD-ASL) and multi-delay ASL (MD-ASL) cerebral blood flow (CBF) and arterial transit time (ATT).

Approach: SD-ASL and MD-ASL were repeated on 9 healthy volunteers 14 days apart. Within-subject coefficients of variation (CoVs) for absolute and relative CBF and ATT were assessed in gray and white matter.

Results: Absolute CBF had 5% lower CoVs for MD-ASL than SD-ASL. Relative CBF was more repeatable with CoVs 3-4 times lower for both scan-types. ATT was more repeatable than CBF for absolute quantification.

Impact: Our repeatability study shows relative CBF has much lower CoV than absolute CBF and therefore relative CBF may be more useful for longitudinal studies. MD-ASL acquisition is preferable, giving lower CoVs for CBF and additional ATT with good repeatability.

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Keywords