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Abstract #4775

Comparing One-Stage and Two-Stage Model Fitting Approaches in Multi-TE ASL for Blood-Brain Barrier Permeability Assessment

Amnah Mahroo1, Klaus Eickel1, and Matthias Günther1
1Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling

Motivation: This study investigates parameter interdependence in multi-echo-time ASL modeling of blood-brain barrier permeability and related parameters.

Goal(s): The goal is to compare one-stage and two-stage fitting approaches for estimating CBF, ATT, Tex, and ITT.

Approach: Using simulations, we conducted a comparative analysis, applying a one-stage, two-compartment model versus a two-stage approach where CBF and ATT were first estimated with the Buxton model.

Results: Our findings show that Tex estimation remained relatively stable in both approaches, but in two-stage approach CBF underestimation propagated errors into ITT, highlighting the need to consider model assumptions and parameter cross-dependencies in two-stage approaches.

Impact: This study shows that two-stage approaches, using different models in each stage, risk error propagation due to parameter cross-dependence. These insights are essential for developing more accurate, clinically applicable BBB imaging models that improve parameter reliability.

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Keywords