Keywords: Arterial Spin Labelling, Arterial spin labelling
Motivation: This study investigates parameter interdependence in multi-echo-time ASL modeling of blood-brain barrier permeability and related parameters.
Goal(s): The goal is to compare one-stage and two-stage fitting approaches for estimating CBF, ATT, Tex, and ITT.
Approach: Using simulations, we conducted a comparative analysis, applying a one-stage, two-compartment model versus a two-stage approach where CBF and ATT were first estimated with the Buxton model.
Results: Our findings show that Tex estimation remained relatively stable in both approaches, but in two-stage approach CBF underestimation propagated errors into ITT, highlighting the need to consider model assumptions and parameter cross-dependencies in two-stage approaches.
Impact: This study shows that two-stage approaches, using different models in each stage, risk error propagation due to parameter cross-dependence. These insights are essential for developing more accurate, clinically applicable BBB imaging models that improve parameter reliability.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords